What Is the 13-Amino-Acid Extension in IGF-1 LR3?
IGF-1 LR3 Pack 1mg
In peptide chemistry, the N-terminal end of a chain is often a key site that binding partners — in this case, IGF-binding proteins — use to recognize and grip a target molecule. Extending this region with additional residues sterically interferes with that recognition without disturbing the separate part of the molecule the IGF-1 receptor binds to.
This 13-residue addition is why IGF-1 LR3 is 83 amino acids long in total, compared to native IGF-1's 70. It is a deliberate, single design choice made by the researchers who originally engineered the analog specifically to solve the IGFBP-sequestration problem discussed elsewhere on this site, not an incidental or naturally occurring variation.
This is a structural-chemistry explanation only. IGF-1 LR3 is listed on revivelab.ae as the IGF-1 LR3 pack (1 mg); this page describes the compound and gives no guidance on its use.
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