How Does IGF-1 LR3 Compare to Des(1-3)IGF-1?
IGF-1 LR3 Pack 1mg
Both analogs target the same region of the IGF-1 molecule — the N-terminus — because published structural research identified that region as central to IGFBP binding. Des(1-3)IGF-1 achieves reduced IGFBP affinity through deletion (removing residues 1 through 3 of native IGF-1), which is a shorter, simpler modification than the extension-plus-substitution approach used to create IGF-1 LR3.
In published in-vitro comparisons, both variants show meaningfully reduced IGFBP binding relative to native IGF-1 and comparable IGF-1 receptor activity to the native hormone. Researchers choosing between them in the literature have generally been guided by experimental design considerations — such as which structural changes are least likely to interfere with a specific assay — rather than one variant being categorically superior to the other.
Des(1-3)IGF-1, like IGF-1 LR3, is an unregulated research chemical rather than an approved pharmaceutical, and neither is stocked, listed, or available to order from REVIVE LAB UAE. This page is general research information only.
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